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Rare cancers collectively contribute a disproportionate fraction of the total burden of cancer. The oncology community is increasingly facing small numbers of patients with each cancer subtype, requiring cooperation and collaboration to complete multicentre trials that advance knowledge and patient care. At the same time, new insights into the biology of rare cancers have led to an explosion in knowledge and development of targeted agents. These insights and techniques are set to revolutionise the care of patients with cancer. However, drug development strategies and the availability of new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and costs of clinical trials. Finding solutions to these problems is imperative to the future of cancer care. We propose that a greater degree of risk sharing is needed than is currently accepted to enable the use of new methods with confidence, and to keep pace with scientific advancement.

Original publication

DOI

10.1016/S1470-2045(14)71153-2

Type

Journal article

Journal

Lancet Oncol

Publication Date

04/2015

Volume

16

Pages

e190 - e194

Keywords

Drug Discovery, Humans, Molecular Targeted Therapy, Neoplasms, Rare Diseases, Research